Effects of Propranolol
نویسنده
چکیده
To evaluate the role of ventricular baroreceptors in humans, we studied the effects of propranolol on reflex vasoconstrictor responses to simulated orthostatic stress. We measured forearm vascular resistance in 10 normal males in the control state and during lower body negative pressure (LBNP) at -10 and -40mm Hg before and after propranolol (0.1 mg/kg i.v.). Baseline forearm vascular resistance showed no significant change: 23.9 3.4 U (± SEM) before vs 28.0 ± 0.5 U after propranolol. Reflex increases in forearm vascular resistance during LBNP at -10 and 40 mm Hg were 5.2 ± 1.2 and 21.2 + 6.6 U before and 3.4 ± 1.2 and 10.6 ± 2.2 U, respectively, after propranolol. Thus, propranolol significant-
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تاریخ انتشار 2005